@article{143586,
  author = {Michael SA Graziano and CSR Taylor and Moore},
  title = {Probing cortical function with electrical stimulation},
  abstract = { <p>
	In a News and Views piece ({\textquotedblleft}Stimulating research on Motor Cortex{\textquotedblright} 2002, 5:714), Strick comments on our recent finding that microstimulation of motor cortex evokes complex, coordinated behavior (1).~ A major concern that he raises is that, {\textquotedblleft}one might ask whether electrical stimulation of the cortex is capable of revealing its function.{\textquotedblright}~ We agree that one should always ask such questions about all experimental methods.~ However, a large body of recent work, conspicuously not cited in Strick{\textquoteright}s piece, successfully probes cortical function using electrical stimulation.~ For example, Newsome and colleagues (2) stimulated monkey visual area MT and influenced the monkey{\textquoteright}s perceptual decisions about the direction of motion of visual stimuli.~ Romo and colleagues (3) stimulated primary somatosensory cortex and influenced the monkey{\textquoteright}s perceptual decisions about tactile stimuli. Shadlen and colleagues (4) stimulated the frontal eye fields and influenced the monkey{\textquoteright}s target selection.~ Many researchers have used electrical stimulation to study functional maps of eye and head movement (5-7).~ We took the well-established protocol of stimulating on a behaviorally relevant time scale and applied it to motor cortex.~ The stimulation durations that we used are within the range of these previous studies, and the current intensities are within the range used in the oculomotor studies.~ As in previous studies, we evoked meaningful behaviors.
</p>
 },
  year = {2002},
  journal = {Nature Neuroscience},
  volume = {5},
  pages = {921},
  url = {https://www.nature.com/articles/nn1002-921},
  language = {eng},
}